Prolactin Adenomas in Senegal: Epidemiological, Diagnostic and Therapeutic Aspects of 89 Cases

Introduction: In Senegal, there is very little data on prolactinomas despite their negative impact couples fertility. Patients and methods: This was a multicentre, retrospective, descriptive, analytical study conducted from 1 January 2008 to 31 December 2022 in the neurosurgery departments of Fann Principal hospitals endocrinology department Abass Ndao Hospital. Results: We included 89 patients, representing prevalence 36.7% among all cases pituitary adenoma. The mean age 35.6 ± 10 years sex ratio 0.34. time consultation 27.1 29 months. Clinical symptoms were dominated by gonadotropic disorders represented galactorrhoea (71 cases, 79.8%), amenorrhoea (61 68.5%), infertility couple (31 34.8%). Fifty-seven (58) patients presented with tumour syndrome (65.2%, including 57 headache (64%), 34 visual (38.2%) 8 dysmorphic (8.9%). Imaging revealed macroadenoma 68.5% cases) extension adenoma 11 (12.4%). hormonal profile isolated lactotropic hypersecretion (80 89.9%) mixed 9 (including concomitant secretion GH ACTH case). All had initially benefited? dopaminergic agonist-based medical treatment. Pituitary surgery effective 45 (50.6%), 44 transsphenoidal approach. Postoperative incidents transient diabetes insipidus (77.7%) cerebrospinal fluid leakage (20%). noted 7 (7.9%) death presenting (100%), macro-adenoma (85.7%), having undergone (42.9%). factors significantly associated prolactinoma young (p < 0.001), female long delay 0.001) microadenoma 0.001). Conclusion: series also demonstrates prolactin adenomas reproductive function. Delayed diagnosis explains predominance macroadenomas, which are source pre- post-operative complications.